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Clinical Pediatrics
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Toxic Epidermal Necrolysis in Children—An Update

Mihaela Ringheanu, MD

Department of Pediatrics, Maimonides Medical Center, Brooklyn, NY

Teresita A. Laude, MD

Department of Pediatrics and Dermatology, Division of Pediatric Dermatology, State University of New York, Health Science Center at Brooklyn, NY

Toxic epidermal necrolysis (TEN) is a relatively rare disease, characterized by generalized erythema, bulla formation, and exfoliation of the epidermis that resembles scalding. It is usually drug-induced and mediated by immune reactions of several types. TEN has to be differentiated from erythema multiforme and Stevens-Johnson syndrome. TEN bears a life-threatening potential and a risk for significant complications such as dehydration; secondary infections; pulmonary, gastrointestinal, and renal involvement; and late scarring with cosmetic and functional implications. Therapeutic interventions include admission in a burn center unit, systemic antibiotics and corticosteroids, topical therapy with antibacterial agents and biological dressings, and supportive measures.

Clinical Pediatrics, Vol. 39, No. 12, 687-694 (2000)
DOI: 10.1177/000992280003901201
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Home page
 The Annals of PharmacotherapyHome page
D. A Alkurtass and A. S Al-Jazairi
Possible Captopril-Induced Toxic Epidermal Necrolysis
Ann. Pharmacother., March 1, 2003; 37(3): 380 - 383.
[Abstract] [Full Text] [PDF]