Clinical Pediatrics

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Connor, D. F.
Right arrow Articles by Davis, H. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Connor, D. F.
Right arrow Articles by Davis, H. T.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Clinical Pediatrics, Vol. 39, No. 1, 15-25 (2000)
DOI: 10.1177/000992280003900102

A Pilot Study of Methyiphenidate, Clonidine, or the Combination in ADHD Comorbid with Aggressive Oppositional Defiant or Conduct Disorder

Daniel F. Connor, MD

Division of Child and Adolescent Psychiatry and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA; Department of Psychiatry, 7th floor, University of Massachusetts Medical School, 55 Lake Ave., North, Worcester, MA 01655

Russell A. Barkley, PhD

Heather T. Davis, RN, MS, CS

Division of Child and Adolescent Psychiatry and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA

A pilot comparison of the safety and efficacy of methylphenidate (MPH) combined with clonidine, clonidine monotherapy, or MPH monotherapy in 6to 16-year-old children diagnosed with attention deficit hyperactivity disorder (ADHD) and comorbid aggressive oppositional defiant disorder or conduct disorder was completed. Study design was a 3-month, randomized, blinded, group comparison with eight subjects per group. No placebo comparison was used. All three treatment groups showed significant improvements in attention deficits, impulsivity, oppositional, and conduct disordered symptoms as assessed by parent and teacher rating scales and laboratory measures. Significant differences among treatment groups were found only on a few measures. Only the clonidine monotherapy group showed significantly decreased fine motor speed. These results suggest the safety and efficacy of clonidine alone or in combination with MPH for the treatment of ADHD and aggressive oppositional and conduct disorders.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
PediatricsHome page
J. Biederman, R. D. Melmed, A. Patel, K. McBurnett, J. Konow, A. Lyne, N. Scherer, and for the SPD503 Study Group
A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Pediatrics, January 1, 2008; 121(1): e73 - e84.
[Abstract] [Full Text] [PDF]


Home page
J Atten DisordHome page
J. G. Wood, J. L. Crager, C. M. Delap, and K. D. Heiskell
Literature Review: Beyond Methylphenidate: Nonstimulant Medications for Youth With ADHD
J Atten Disord, November 1, 2007; 11(3): 341 - 350.
[Abstract] [PDF]


Home page
Arch. Dis. Child.Home page
C R Steer
Managing attention deficit/hyperactivity disorder: unmet needs and future directions
Arch. Dis. Child., February 1, 2005; 90(suppl_1): i19 - i25.
[Abstract] [Full Text] [PDF]


Home page
FocusHome page
J. D. Burke, R. Loeber, and B. Birmaher
Oppositional Defiant Disorder and Conduct Disorder: A Review Of The Past 10 Years, Part II
Focus, October 1, 2004; 2(4): 558 - 576.
[Abstract] [Full Text] [PDF]


Home page
J Atten DisordHome page
D. S. Bennett, M. Pitale, V. Vora, and A. A. Rheingold
Reactive vs. proactive antisocial behavior: Differential correlates of child ADHD symptoms?
J Atten Disord, May 1, 2004; 7(4): 197 - 204.
[Abstract] [PDF]


Home page
J Atten DisordHome page
V. Bhatara, M. Feil, K. Hoagwood, B. Vitiello, and B. Zima
National trends in concomitant psychotropic medication with stimulants in pediatric visits: Practice versus knowledge
J Atten Disord, May 1, 2004; 7(4): 217 - 226.
[Abstract] [PDF]


Home page
Am. J. PsychiatryHome page
D. J. Safer, J. M. Zito, and S. dosReis
Concomitant Psychotropic Medication for Youths
Am J Psychiatry, March 1, 2003; 160(3): 438 - 449.
[Abstract] [Full Text] [PDF]


Home page
Journal of Emotional and Behavioral DisordersHome page
D. F. Connor, R. T. Boone, R. J. Steingard, I. D. Lopez, and R. H. Melloni JR
Psychopharmacology and Aggression: II. A Meta-Analysis of Nonstimulant Medication Effects on Overt Aggression-Related Behaviors in Youth with SED
Journal of Emotional and Behavioral Disorders, January 1, 2003; 11(3): 157 - 168.
[Abstract] [PDF]


Home page
Am. J. PsychiatryHome page
L. Scahill, P. B. Chappell, Y. S. Kim, R. T. Schultz, L. Katsovich, E. Shepherd, A. F.T. Arnsten, D. J. Cohen, and J. F. Leckman
A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder
Am J Psychiatry, July 1, 2001; 158(7): 1067 - 1074.
[Abstract] [Full Text]


Home page
J. Pharmacol. Exp. Ther.Home page
M. J. Millan, F. Lejeune, A. Gobert, M. Brocco, A. Auclair, C. Bosc, J.-M. Rivet, J.-M. Lacoste, A. Cordi, and A. Dekeyne
S18616, a Highly Potent Spiroimidazoline Agonist at alpha 2-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine
J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 1206 - 1222.
[Abstract] [Full Text]