This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Connor, D. F. Articles by Davis, H. T. Search for Related Content PubMed PubMed Citation Articles by Connor, D. F. Articles by Davis, H. T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Attention Deficit Hyperactivity Disorder Hazardous Substances DB CLONIDINE METHYLPHENIDATE Social Bookmarking                   What's this?

A Pilot Study of Methyiphenidate, Clonidine, or the Combination in ADHD Comorbid with Aggressive Oppositional Defiant or Conduct Disorder

Division of Child and Adolescent Psychiatry and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA; Department of Psychiatry, 7th floor, University of Massachusetts Medical School, 55 Lake Ave., North, Worcester, MA 01655

Russell A. Barkley, PhD

Heather T. Davis, RN, MS, CS

Division of Child and Adolescent Psychiatry and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA

A pilot comparison of the safety and efficacy of methylphenidate (MPH) combined with clonidine, clonidine monotherapy, or MPH monotherapy in 6to 16-year-old children diagnosed with attention deficit hyperactivity disorder (ADHD) and comorbid aggressive oppositional defiant disorder or conduct disorder was completed. Study design was a 3-month, randomized, blinded, group comparison with eight subjects per group. No placebo comparison was used. All three treatment groups showed significant improvements in attention deficits, impulsivity, oppositional, and conduct disordered symptoms as assessed by parent and teacher rating scales and laboratory measures. Significant differences among treatment groups were found only on a few measures. Only the clonidine monotherapy group showed significantly decreased fine motor speed. These results suggest the safety and efficacy of clonidine alone or in combination with MPH for the treatment of ADHD and aggressive oppositional and conduct disorders.

Clinical Pediatrics, Vol. 39, No. 1, 15-25 (2000)
DOI: 10.1177/000992280003900102


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. Biederman, M. C. Monuteaux, T. Spencer, T. E. Wilens, and S. V. Faraone Do Stimulants Protect Against Psychiatric Disorders in Youth With ADHD? A 10-Year Follow-up Study Pediatrics, July 1, 2009; 124(1): 71 - 78. [Abstract] [Full Text] [PDF]

				J. Biederman, R. D. Melmed, A. Patel, K. McBurnett, J. Konow, A. Lyne, N. Scherer, and for the SPD503 Study Group A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder Pediatrics, January 1, 2008; 121(1): e73 - e84. [Abstract] [Full Text] [PDF]

				J. G. Wood, J. L. Crager, C. M. Delap, and K. D. Heiskell Literature Review: Beyond Methylphenidate: Nonstimulant Medications for Youth With ADHD J Atten Disord, November 1, 2007; 11(3): 341 - 350. [Abstract] [PDF]

				C R Steer Managing attention deficit/hyperactivity disorder: unmet needs and future directions Arch. Dis. Child., February 1, 2005; 90(suppl_1): i19 - i25. [Abstract] [Full Text] [PDF]

				J. D. Burke, R. Loeber, and B. Birmaher Oppositional Defiant Disorder and Conduct Disorder: A Review Of The Past 10 Years, Part II Focus, October 1, 2004; 2(4): 558 - 576. [Abstract] [Full Text] [PDF]

				D. S. Bennett, M. Pitale, V. Vora, and A. A. Rheingold Reactive vs. proactive antisocial behavior: Differential correlates of child ADHD symptoms? J Atten Disord, May 1, 2004; 7(4): 197 - 204. [Abstract] [PDF]

				V. Bhatara, M. Feil, K. Hoagwood, B. Vitiello, and B. Zima National trends in concomitant psychotropic medication with stimulants in pediatric visits: Practice versus knowledge J Atten Disord, May 1, 2004; 7(4): 217 - 226. [Abstract] [PDF]

				D. J. Safer, J. M. Zito, and S. dosReis Concomitant Psychotropic Medication for Youths Am J Psychiatry, March 1, 2003; 160(3): 438 - 449. [Abstract] [Full Text] [PDF]

				D. F. Connor, R. T. Boone, R. J. Steingard, I. D. Lopez, and R. H. Melloni JR Psychopharmacology and Aggression: II. A Meta-Analysis of Nonstimulant Medication Effects on Overt Aggression-Related Behaviors in Youth with SED Journal of Emotional and Behavioral Disorders, January 1, 2003; 11(3): 157 - 168. [Abstract] [PDF]

				H. Niederhofer, W. Staffen, and A. Mair A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder J Psychopharmacol, January 1, 2003; 17(1): 113 - 119. [Abstract] [PDF]

				L. Scahill, P. B. Chappell, Y. S. Kim, R. T. Schultz, L. Katsovich, E. Shepherd, A. F.T. Arnsten, D. J. Cohen, and J. F. Leckman A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder Am J Psychiatry, July 1, 2001; 158(7): 1067 - 1074. [Abstract] [Full Text]

				M. J. Millan, F. Lejeune, A. Gobert, M. Brocco, A. Auclair, C. Bosc, J.-M. Rivet, J.-M. Lacoste, A. Cordi, and A. Dekeyne S18616, a Highly Potent Spiroimidazoline Agonist at alpha 2-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 1206 - 1222. [Abstract] [Full Text]