Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
Clinical Pediatrics
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bachrach, S. J.
Right arrow Articles by Trzcinski, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bachrach, S. J.
Right arrow Articles by Trzcinski, K.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Cerebral Palsy
*Salivary Gland Disorders
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Use of Glycopyrrolate and Other Anticholinergic Medications for Sialorrhea in Children with Cerebral Palsy

Steven J. Bachrach, MD

Rhonda S. Walter, MD

Kathleen Trzcinski, MSN, CRNP

Department of Pediatrics and Department of Nursing, duPont Hospital for Children, Wilmington, Delaware; Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania

Fifty-four parents/caretakers of children with cerebral palsy were surveyed regarding their use of antisialorrheic medication for excessive drooling. Glycopyrrolate was used by 37 of 41 respondents, with significant improvement in drooling noted in the vast majority (95%) of cases as indicated by a five-point rating scale. Side effects (dry mouth, thick secretions, urinary retention, or flushing) surfaced in almost half (44%) of the patients but necessitated discontinuation of pharmacologic treatment in less than a third. While larger clinical studies are needed, our preliminary data indicate a trial of glycopyrrolate should be considered in children with cerebral palsy where drooling is a significant problem.

Clinical Pediatrics, Vol. 37, No. 8, 485-490 (1998)
DOI: 10.1177/000992289803700805
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am J Health Syst PharmHome page
P. E. Kintzel, S. L. Chase, W. Thomas, D. M. Vancamp, and E. A. Clements
Anticholinergic medications for managing noisy respirations in adult hospice patients
Am. J. Health Syst. Pharm., March 1, 2009; 66(5): 458 - 464.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. H. Jongerius, F. J.A. v. d. Hoogen, J. v. Limbeek, F. J. Gabreels, K. v. Hulst, and J. J. Rotteveel
Effect of Botulinum Toxin in the Treatment of Drooling: A Controlled Clinical Trial
Pediatrics, September 1, 2004; 114(3): 620 - 627.
[Abstract] [Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
M. H. Hart
Botulinum Toxin: A Treatment for Drooling in CP Patients?
AAP Grand Rounds, November 1, 2001; 6(5): 58 - 58.
[Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
R. J. Mier, S. J. Bachrach, R. C. Lakin, T. Barker, J. Childs, and M. Moran
Treatment of Sialorrhea With Glycopyrrolate: A Double-blind, Dose-Ranging Study
Arch Pediatr Adolesc Med, December 1, 2000; 154(12): 1214 - 1218.
[Abstract] [Full Text] [PDF]