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Effectiveness of Short-Course, Intermittent Chemotherapy for Tuberculosis in Young Infants Aged Less Than 6 Months

Department of Pediatrics, Pediatric Pulmonology Unit, Hacettepe University Faculty of Medicine, Ankara-Turkey

Ayhan Göçcmen, MD

Embiya Dilber, MD

Ugur OzGelik, MD

Department of Pediatrics, Pediatric Pulmonology Unit, Hacettepe University Faculty of Medicine, Ankara-Turkey

In order to determine the efficacy of short-course intermittent chemotherapy for tuberculosis in young infants less than 6 months of age, 15 newly diagnosed infants were treated with isoniazid (10-15 mg/kg) and rifampin (10-15 mg/kg), with/without streptomycin (30 mg/kg), daily for 15 days followed by similar doses of isoniazid and rifampin twice a week for another 8.5 months. The follow-up period ranged from 1 to 10 years. No patient demonstrated relapse following the termination of the treatment. These results suggest that short-course, intermittent treatment may be safe and effective for treating tuberculosis in young infants.

Clinical Pediatrics, Vol. 37, No. 7, 433-436 (1998)
DOI: 10.1177/000992289803700706


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