This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Barton, L. L. Articles by Hulett, R. L. Search for Related Content PubMed PubMed Citation Articles by Barton, L. L. Articles by Hulett, R. L. Social Bookmarking                         What's this?

Gastrointestinal Complications of Chronic Granulomatous Disease: Case Report and Literature Review

Department of Pediatrics and The Steele Memorial Children's Research Center; Section of Pediatric Infectious Diseases/3403, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, PO Box 245073, Tucson, AZ 85724-5073

Sosan L. Moussa, MHS, MD

Rodrigo G. Villar, MD

Department of Pediatrics and The Steele Memorial Children's Research Center, Tucson, AZ

Rebecca L. Hulett, MD

The Department of Radiology, The University of Arizona, Tucson, AZ

Chronic granulomatous disease (CGD), an inherited disorder of phagocytic leukocyte function, is characterized by recurrent infections with catalase-positive organisms. Gastrointestinal (GI) tract involvement, present in the majority of affected individuals, may be present initially and recurrently, mimics other entities such as inflammatory bowel disease, and causes substantive morbidity and mortality. Disorders of motility, ulceration, obstruction, and infection (e.g., abscesses) occur from the mouth to the anus and stereotypically manifest with vomiting, diarrhea, abdominal pain, weight loss, and fever. Careful physical examination, in concert with appropriate diagnostic studies, is necessary to delineate intraabdominal pathologic processes. Abdominal radiographs, ultrasonography, computerized tomography, and endoscopy are useful ancillary diagnostic procedures. Drainage of accessible abscesses, antimicrobial therapy based on organisms cultured from blood and tissue, and interferon gamma may lead to suppression or eradication of infections and resolution of symptoms. Corticosteroids are useful for gastric outlet obstruction and sulfasalazine and cyclosporine for large bowel disease. Gallbladder dysfunction may be ameliorated, as in our pa tient, with administration of cholestyramine.

Clinical Pediatrics, Vol. 37, No. 4, 231-236 (1998)
DOI: 10.1177/000992289803700403


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. Samarghitean, C. Ortutay, and M. Vihinen Systematic Classification of Primary Immunodeficiencies Based on Clinical, Pathological, and Laboratory Parameters J. Immunol., December 1, 2009; 183(11): 7569 - 7575. [Abstract] [Full Text] [PDF]

				M. Douvoyiannis, L. Bordy, and E. Fakioglu An Infant with Diffuse Lung Masses Clinical Pediatrics, July 1, 2009; 48(6): 686 - 689. [Abstract] [PDF]

				R. B. Johnston Jr and L. L. Barton Perianal Abscesses Pediatrics, February 1, 2008; 121(2): 447 - 447. [Full Text] [PDF]

				K. Bedard and K.-H. Krause The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Physiol Rev, January 1, 2007; 87(1): 245 - 313. [Abstract] [Full Text] [PDF]

				M. Lukela, D. DeGuzman, S. Weinberger, and S. Saint Unfashionably Late N. Engl. J. Med., January 6, 2005; 352(1): 64 - 69. [Full Text] [PDF]

				B. E. Marciano, S. D. Rosenzweig, D. E. Kleiner, V. L. Anderson, D. N. Darnell, S. Anaya-O'Brien, D. M. Hilligoss, H. L. Malech, J. I. Gallin, and S. M. Holland Gastrointestinal Involvement in Chronic Granulomatous Disease Pediatrics, August 1, 2004; 114(2): 462 - 468. [Abstract] [Full Text] [PDF]

				Y Moltyaner, W H Geerts, D W Chamberlain, P G Heyworth, D Noack, J Rae, J J Doyle, and G P Downey Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis Thorax, December 1, 2003; 58(12): 1096 - 1098. [Abstract] [Full Text] [PDF]

				P. D. Arkwright, M. Abinun, and A. J. Cant Autoimmunity in human primary immunodeficiency diseases Blood, April 15, 2002; 99(8): 2694 - 2702. [Abstract] [Full Text] [PDF]

				M G Schäppi, V V Smith, D Goldblatt, K J Lindley, and P J Milla Colitis in chronic granulomatous disease Arch. Dis. Child., February 1, 2001; 84(2): 147 - 151. [Abstract] [Full Text]