| Sign In to gain access to subscriptions and/or personal tools. |
Insulin Secretion and Sensitivity in Healthy African-American vs American White ChildrenDivision of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, School of Medicine, Pittsburgh, PA Racial differences in insulin secretion and insulin sensitivity in healthy children were studied by administering a 2-hour hyperglycemic clamp (225 mg/dL) to 14 black and 16 white healthy adolescents (Tanner II-V), and 12 black and 11 white prepubertal children, matched for age, body mass index, and Tanner I pubertal development. In prepubertal children, fasting and first-phase insulin concentrations were higher in blacks compared with whites (14.7 ±1.3 vs 10.4 ±1.2, P=0.02, and 76.9 ±6.8 vs 52.1 ±6.4 µu/mL, P=0.016). There were no differences in second- phase insulin levels and insulin sensitivity index. In pubertal adolescents, first-phase and second- phase insulin concentrations were higher in blacks compared with whites (first-phase: 157.3 ±18.3 vs 77.0 ±8.7 µu/mL, P=0.0003; second-phase: 175.0 ±24.3 vs 108.7 ±8.8 µu/mL, P=0.012). Insulin sensitivity index was 35% lower in black adolescents compared with whites (P=0.02). These findings indicate that significant differences in insulin secretion and sensitivity are detectable early in childhood in healthy African-American vs American whites. However, genetic (race) vs environ mental factors (physical activity/fitness, energy balance) should be carefully scrutinized as potential factors responsible for such differences. Clin Pediatr. 1998;37:81-88
Clinical Pediatrics, Vol. 37, No. 2,
81-88 (1998) This article has been cited by other articles:
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||
 |
|
|
 |
|
Sign In to gain access to subscriptions and/or personal tools.
