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Acanthosis Nigricans as a Risk Factor for Non-Insulin Dependent Diabetes Mellitus

Departments of Internal Medicine, Pediatrics, and Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, The Winnebago Tribe of Nebraska, and the Winnebago PHS Indian Health Service Hospital, Winnebago, Nebraska

Charles R. Gilkison

Departments of Internal Medicine, Pediatrics, and Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, The Winnebago Tribe of Nebraska, and the Winnebago PHS Indian Health Service Hospital, Winnebago, Nebraska

Michele M. Smith

Anna M. Bosma

Departments of Internal Medicine, Pediatrics, and Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, The Winnebago Tribe of Nebraska, and the Winnebago PHS Indian Health Service Hospital, Winnebago, Nebraska

Bruce S. Keenan

Departments of Internal Medicine, Pediatrics, and Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, The Winnebago Tribe of Nebraska, and the Winnebago PHS Indian Health Service Hospital, Winnebago, Nebraska

Manubai Nagamani

Departments of Internal Medicine, Pediatrics, and Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, The Winnebago Tribe of Nebraska, and the Winnebago PHS Indian Health Service Hospital, Winnebago, Nebraska

The prevalences of obesity and of non-insulin dependent diabetes mellitus (NIDDM) have increased in the United States population over the past two decades, and thus diabetes preven tion has become a major concern of public health agencies such as the National Institutes of Health. Identification of individuals at risk for diabetes is an essential first step in designing and implementing intervention programs. Insulin resistance is the hallmark of the pathophysiology of NIDDM. Subjects with hyperinsulinemia, impaired glucose tolerance, or gestational diabetes are well accepted as being at high risk for diabetes. We propose that the easily identifiable skin lesion, acanthosis nigricans, is common in the major minority groups in the United States and that its presence is a surrogate for laboratory-determined hyperinsulinemia. Clin Pediatr. 1998;37:73-80

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