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Clinical Pediatrics
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Sleep Apnea in Patients Receiving Growth Hormone

James M. Gerard

Department of Pediatrics, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital

Luigi Garibaldi

Department of Pediatrics, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital, Division of Endocrinology, Saint Lousi University Health Sciences Center and Cardinal Glennon Children's Hospital

Susan E. Myers

Department of Pediatrics, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital, Division of Endocrinology, Saint Lousi University Health Sciences Center and Cardinal Glennon Children's Hospital

Thomas Aceto, JR

Department of Pediatrics, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital, Division of Endocrinology, Saint Lousi University Health Sciences Center and Cardinal Glennon Children's Hospital

Suresh Kotagal

Department of Neurology, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital

Vincent P. Gibbons

Department of Neurology, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital

John Stith

Department of Otolaryngology, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital

Colleen Weber

Department of Pediatrics, Saint Louis University Health Sciences Center and Cardinal Glennon Children's Hospital, Division of Endocrinology, Saint Lousi University Health Sciences Center and Cardinal Glennon Children's Hospital

Among 145 patients treated with recombinant human growth hormone (GH), four devel oped sleep apnea (two obstructive, two mixed) associated with tonsillar and adenoidal hypertrophy in three. These four patients had no local risk factors predisposing to upper airway obstruction (i.e., frequent pharyngitis or sinusitis). Clinical and/or polysomnographic features of sleep apnea improved following cessation of GH therapy in one patient, and following tonsillectomy and adenoidectomy in all patients. The present observations indicate that, albeit rarely, obstructive and/or central sleep apnea may occur in children treated with GH. Polysomnography should be considered if symptoms of snoring, interrupted sleep, daytime somnolence—particularly if associated with tonsillar hypertrophy—appear in children during GH therapy.

Clinical Pediatrics, Vol. 36, No. 6, 321-326 (1997)
DOI: 10.1177/000992289703600602
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