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A Double-Blind Taste Comparison of Pediatric Antibiotic Suspensions

Benjamin Estrada, MD

Rodolfo E. Begue, MD

Ayesha Mirza, MD

David A. Travillion, RPh

Mathew P. Thomas, PharmD

Division of Infectious Diseases/Immunology, and Children's Hospital, New Orleans, Louisia

This study examined the palatability of 22 antimicrobial suspensions by using five independent categories for scoring: appearance, smell, texture, taste, and aftertaste. The likely overall influence on patient compliance was also evaluated. Drugs were compared within their respective classes. The only antibiotics judged to be so unpalatable as to potentiallyjeopardize compliance were dicloxacillin, oxacillin, erythromycin/sulfisoxazole, and cefpodoxime. Among the penicillins, amoxicillin and ampicillin were preferred. Azithromycin was slightly superior to erythromycin and clarithromycin within the macrolide class. Many cephalosporins were ranked quite high, the best being loracarbef, cefadroxyl, cefprozil, and cefixime.

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