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Clinical Pediatrics
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Mold Allergyisa is a sk Factor for Persistent Cold-Like Symptoms in Children

Shih-Wen Huang, MD

Division of Allergy/Immunology, Department of Pediatrics, Box 100296, University of Florida College of Medicine, Gainesville, Florida 32610

James W. Kimbrough, PhD

Department of Plant Pathology, University of Florida

In winter, children with mold allergy may develop persistent cold-like symptoms (PCLS) that often defy conventional therapy. To investigate the cause of PCLS, we enrolled 44 children (25 with PCLS and 19 controls) in a 2-year study to compare their clinical symptoms and the mold count in their homes. Children with PCLS had a higher percent of eosinophils in nasal smears as compared with those without PCLS (32% vs 26%). On a scale of 0 to 3, the PCLS group had higher symptom scores (P<0.001 for all symptoms): bloodshot eyes (2.92 vs 0.79), mouth breathing (2.04 vs 0.68), rhinorrhea (2.48 vs 0.89), nasal voice (2.68 vs 1.00), postnasal drip (2.64 vs 0.47), and headache (2.72 vs 0.53) than the non-PCLS group. The clinical scores also correlated significantly with the mold count in the home (the rvalue ranged from 0.6716 to 0.7450). We conclude that management of children with PCLS should include decreasing humidity and enforcing environmental control to eradicate mold from inside the homes.

Clinical Pediatrics, Vol. 36, No. 12, 695-699 (1997)
DOI: 10.1177/000992289703601205
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