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Clinical Pediatrics, Vol. 35, No. 7, 349-351 (1996)
DOI: 10.1177/000992289603500703

Increased Creatine Kinase Brain Isoenzyme Concentration in Cerebrospinal Fluid with Meningitis

M. Nussinovitch, M.D.

Department of Pediatrics "C," Children's Medical Center of Israel, Petach Tikvah, Israel

G. Klinger, M.D.

G. Soen, M.D.

Department of Pediatrics "C," Children's Medical Center of Israel, Petach Tikvah, Israel

A. Magazanik, M.D.

Laboratory of Clinical Chemistry, Hasharon Medical Center, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel

B. Volovitz, M.D.

I. Varsano, M.D.

Department of Pediatrics "C," Children's Medical Center of Israel, Petach Tikvah, Israel

A. Nussinovitch, Ph.D.

Hebrew University of Jerusalem, Department of Biochemistry Food-Science and Nutrition, Faculty of Agriculture, Rehovot, Israel

CPK-BB (CK-BB) isoenzyme is an intracellular enzyme released in various neurologic conditions, including central nervous system (CNS) infections. Activity of CK-BB in cerebrospinal fluid (CSF) was determined in 80 children by electrophoresis and densitometry. The possible correlation between CNS infection and CK concentrations was assessed. Significantly elevated concentrations of CK activity (P <0.01) in the CSF were found in children with bacterial meningitis as compared with children with either aseptic meningitis or normal CSF findings. The data suggest the possibility of utilizing CSF CK activity to differentiate between bacterial and viral meningitis in situations where a routine CSF examination is inconclusive.


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