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Clinical Pediatrics
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Amphotercin B Lipid Complex Treatment of a Leukemic Child wlth Disseminated Fusarrium solani Infection

Thomas S. Patterson, M.D.

Department of Pediatrics and Steele Memorial Children's Research Center, The University of Arizona, Tucson, AZ 85724

Leslie L. Barton, M.D.

University of Arizona Health Sciences Center, Steele Memorial Children's Research Center, Department of Pediatrics/3403, 1501 North Campbell Avenue, PO Box 245073, Tucson, AZ 85724-5073

Ziad M. Shehab, M.D.

John J. Hutter, M.D.

Department of Pediatrics and Steele Memorial Children's Research Center, The University of Arizona, Tucson, AZ 85724

We report a case of Fusarium solani infection in a 2'2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.

Clinical Pediatrics, Vol. 35, No. 5, 257-260 (1996)
DOI: 10.1177/000992289603500505
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