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Clinical Pediatrics
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Intravenous Theophylline in Pediatric Status Asthmaticus

A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

James P. Bien

Children's Hospital Medical Center, Cincinnati, Ohio, and The University of Cincinnati College of Medicine, Ohio

Miriam D. Bloom

Children's Hospital Medical Center, Cincinnati, Ohio, and The University of Cincinnati College of Medicine, Ohio

Robert L. Evans

Children's Hospital Medical Center, Cincinnati, Ohio, and The University of Cincinnati College of Medicine, Ohio

Bonny Specker

Children's Hospital Medical Center, Cincinnati, Ohio, and The University of Cincinnati College of Medicine, Ohio

Kevin P. O'Brien

Children's Hospital Medical Center, Cincinnati, Ohio, and The University of Cincinnati College of Medicine, Ohio

This study was conducted to determine whether intravenous theophylline, added to inhaled albuterol and intravenous methylprednisolone, provides a clinically significant benefit in the treatment of pediatric status asthmaticus. Patients aged 2 to 10 years were randomized to receive either intravenous theophylline or placebo. All patients received aerosolized albuterol and intravenous methylprednisolone. There was no difference between groups in the improvement of a clinical asthma score over time, in oxygen requirement, or in the number of albuterol treatments required. Theophylline group patients experienced more nausea, emesis, and insomnia. We conclude that there is no benefit in adding theophylline to treatment with methylprednisolone and albuterol for pediatric status asthmaticus. Furthermore, there are significantly more adverse effects associated with the use of theophylline.

Clinical Pediatrics, Vol. 34, No. 9, 475-481 (1995)
DOI: 10.1177/000992289503400905
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 Journal of Pharmacy PracticeHome page
J. A. Everett
Alternatives to Standard Status Asthmaticus Therapy
Journal of Pharmacy Practice, June 1, 1997; 10(3): 186 - 199.
[Abstract] [PDF]