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Clinical Pediatrics, Vol. 34, No. 6, 290-299 (1995)
DOI: 10.1177/000992289503400601

Prediction of 12-Month Neurodevelopmental Outcome From a 6-Month Neurologic Examination in Premature Infants

Susan R. Wildin

Department of Pediatrics, Child Development, University of Texas Medical Branch, Galveston

Anne Anderson

Department of Neurology, Pediatric Neurology, Baylor College of Medicine, Houston

Marilyn Woodside

Department of Neurology, Pediatric Neurology, University of Texas Health Science Center, Houston

Paul Swank

Department of Educational Psychology, University of Houston, Houston

Karen Smith

Department of Pediatrics, Child Development, University of Texas Medical Branch, Galveston

Susan Denson

Department of Pediatrics, Neonatology, University of Texas Health Science Center, Houston

Susan Landry

Department of Pediatrics, Developmental Pediatrics, University of Houston Health Science Center, Houston

This study examined whether a neurologic examination at 6 months of age is predictive of neurodevelopmental outcome at 12 months in very-low-birth-weight (VLBW) infants. A neurologic examination and the Bayley Scales of Infant Development were performed at 6 and 12 months with VLBW infants and full-term (FT) controls. VLBW infants were categorized based on early medical complications. High-risk (HR) infants had diagnoses of bronchopulmonary dysplasia, pulmonary immaturity, grade III or IV intraventricular hemorrhage, and/or periventricular leukomalacia. VLBW infants with other diagnoses were placed in the low-risk (LR) group. Total neurologic scores (NS) improved over time for all three groups but improved more for HR infants, who had more abnormal NS at both time points; NS at 6 months predicted neurologic and developmental scores at 12 months for all three groups, but the relation between 6-and 12-month outcomes was strongest for the HR infants. The neurologic examination may be helpful in assessing VLBW infants' need for referral to early childhood intervention programs.


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J Child NeurolHome page
A. Anderson, P. Swank, S. Wildin, S. Landry, and K. Smith
Modeling Analysis of Change in Neurologic Abnormalities in Children Born Prematurely: A Novel Approach
J Child Neurol, August 1, 1999; 14(8): 502 - 508.
[Abstract] [PDF]