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Clinical Pediatrics
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Bone Mineral Content in Nephrotic Children on Long-Term, Alternate-Day Prednisone Therapy

Cesare Polito

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Angela La Manna

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Nicola Todisco

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Ersilia Cimmaruta

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Giuseppa Sessa

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Maria Pirozzi

Department of Pediatrics, Second University of Naples, Third Pediatric Clinic, Naples, Italy

Bone mineral content (BMC) was measured by single-photon absorptiometry in 24 children with steroid-dependent, minimal-lesion nephrotic syndrome after 1 to 6.3 years of alternate-day prednisone therapy and in a sex- and age-matched control group. Bone mineral content was -0.002 ± 1.2 standard deviation scores in patients and 0.3 ± 1.4 in controls ( t = 1.17; P = 0.25). No significant relation was found between BMC in patients and the amount of prednisone taken or the duration of therapy. Alternate-day prednisone therapy at doses usually needed to keep children with steroid-dependent nephrotic syndrome under control does not significantly affect BMC.

Clinical Pediatrics, Vol. 34, No. 5, 234-236 (1995)
DOI: 10.1177/000992289503400501
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