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Clinical Pediatrics
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Impact on Empiric Treatment of Group A Streptococcal Pharyngitis Using an Optical Immunoassay

Richard Harris

Department of Clinical Investigation, Fitzsimons Army Medical Center

Donald Paine

Department of Clinical Investigation, Fitzsimons Army Medical Center

Robert Wittler

Department of Pediatrics, Fitzsimons Army Medical Center, Aurora, Colorado

Frederic Bruhn

Department of Pediatrics, Fitzsimons Army Medical Center, Aurora, Colorado

The potential impact of using a rapid diagnostic test (Strep A OIA) on detection and treatment of group A ß-hemolytic streptococcal (GABHS) pharyngitis in a large-volume pediatric and adolescent clinic was examined. Of 519 swabs processed for both culture and the OIA test, 114 were culture-positive for GABHS compared with 133 positive by the OIA test, for an agreement of 94%. OIA test sensitivity compared with culture was 96%, and specificity was 94%. Forty-seven percent of all study patients were empirically placed on antibiotics. In-clinic OIA testing could have reduced inappropriate therapy and been a cost-effective alternative to culture.

Clinical Pediatrics, Vol. 34, No. 3, 122-127 (1995)
DOI: 10.1177/000992289503400301
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Home page
 Arch Pediatr Adolesc MedHome page
T. A. Schlager, G. A. Hayden, W. A. Woods, S. M. Dudley, and J. O. Hendley
Optical Immunoassay for Rapid Detection of Group A {beta}-Hemolytic Streptococci: Should Culture Be Replaced?
Arch Pediatr Adolesc Med, March 1, 1996; 150(3): 245 - 248.
[Abstract] [PDF]