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Clinical Pediatrics
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ALUMINUM HYDROXIDE
*DIMETHICONE
*MAGNESIUM COMPOUNDS
*MAGNESIUM HYDROXIDE
*SIMETHICONE
Medline Plus Health Information
*Rickets
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Rickets Secondary to Phosphate Depletion

A Sequela of Antacid Use in Infancy

Enikö K. Pivnick

Department of Pediatrics, The University of Tennessee

Natalie C. Kerr

Department of Ophthalmology University of Massachusetts Worcester. Massachusetts

Robert A. Kaufman

Department of Pediatrics, The University of Tennessee, Memphis, Department of Radiology The University of Tennessee, Memphis,, LeBonheur Children's Hospital Memphis, Tennessee

Deborah P. Jones

Department of Pediatrics, The University of Tennessee

Russell W. Chesney

Department of Pediatrics, The University of Tennessee

Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.

Clinical Pediatrics, Vol. 34, No. 2, 73-78 (1995)
DOI: 10.1177/000992289503400202
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This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
A. Pattaragarn and U. S. Alon
Antacid-Induced Rickets in Infancy
Clinical Pediatrics, July 1, 2001; 40(7): 389 - 393.
[Abstract] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
R. W. Chesney
A New Form of Rickets During Infancy: Phosphate Depletion-Induced Osteopenia Due to Antacid Ingestion
Arch Pediatr Adolesc Med, December 1, 1998; 152(12): 1168 - 1169.
[Full Text] [PDF]