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Microalbuminuria in an Adolescent Cohort With Insulin-Dependent Diabetes Mellitus

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Wayne R. Waz, M.D.

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Linda C. Duffy, Ph.D.

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Mark W. Sheldon, M.D.

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Susana P. Campos

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Christine H. Albini, M.D., Ph.D.

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

Leonard G. Feld, M.D., Ph.D.

Children's Hospital of Buffalo, Department of Pediatrics, Children's Division of Endocrinology - Diabetes & Nephrology, State University of New York at Buffalo

To document the incidence of microalbuminuria in children and adolescents with longstanding insulin-dependent diabetes mellitus (IDDM) and to compare the clinical characteristics and determinant risk factors of those with and without microalbuminuria, 135 adolescent patients with IDDM for 5 years or longer were evaluated. The study population was divided on the basis of microalbumin excretion into normal (<20 µg/min), incipient (20-200 µg/min), and overt (>200 µg/min) nephropathy groups. There were 106 patients in the normal group, 24 patients in the incipient group, and five in the overt nephropathy group. Glycosylated hemoglobin, cholesterol concentration, and glomerular filtration rate (GFR) were analyzed. The incidence of incipient and overt nephropathy was 17.8% and 3.7%, respectively. Mean cholesterol concentration in the incipient and overt nephropathy groups (208 ± 39 mg/dL [5.4 ± 1.0 mmol/L] ) and 227 ± 49 mg/dL [5.9 ± 1.3 mmol/L] , respectively) was significantly higher than the normal group (186 ± 37 mg/dL [4.8 ± 0.9 mmol/L] P<0.05). Similarly, systolic and diastolic blood pressures were significantly higher in the incipient and overt nephropathy groups compared to the normal group. This study confirms the high incidence of incipient and overt nephropathy in adolescents with IDDM early in the course of the disease.

Clinical Pediatrics, Vol. 34, No. 1, 12-17 (1995)
DOI: 10.1177/000992289503400103


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