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Changing Pattern of Glomerular Disease at Beijing Children's Hospital

Division of Pediatric Nephrology, Beijing Children's Hospital, Beijing, China

Ying Shen

Division of Pediatric Nephrology, Beijing Children's Hospital, Beijing, China

Leonard G. Feld

Division of Pediatric Nephrology, The Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, New York

F. Bruder Stapleton

Division of Pediatric Nephrology, The Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, New York

Current clinical experience with glomerular disease at a pediatric referral center in Beijing, China, was reviewed. In 1992, renal disorders accounted for 505 of a total 6,885 (7.3%) pediatric medical discharges. Acute glomerulonephritis accounted for 30% of renal diagnoses, while nephrotic syndrome accounted for 28% and Henoch-Schönlein purpura nephritis accounted for 16% of renal disease. Mortality in children with renal disease was 0.4% (two of 505). All children with acute glomerulonephritis recovered or improved at last follow-up, regardless of the relationship to a streptococcal infection. In children with uncomplicated nephrotic syndrome, 91 % had a complete or partial response to corticosteroids. Nephritis developed in 81 of 278 patients with Henoch-Schönlein purpura (29%). Since 1956, a dramatic decrease in the diagnosis of acute glomerulonephritis has occurred at this pediatric hospital. Nephrotic syndrome, in contrast, has increased from 45.3 cases per year in the 1956-to-1965 decade to 146 cases annually in the period from 1986 to 1992. Similarly, Henoch-Schönlein purpura has increased from 45.3 cases annually in the 1956-to-1965 period to 238 cases per year in the past 6 years. The incidence of nephritis in patients with Henoch-Schönlein purpura has remained constant at 29% in the past 36 years. These data should be helpful for individuals and institutions who are planning educational or clinical collaborations with pediatric nephrologists in China.

Clinical Pediatrics, Vol. 33, No. 9, 542-547 (1994)
DOI: 10.1177/000992289403300906


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