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Clinical Pediatrics
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Is Treatment of Acute Otitis Media With Once-a-Day Amoxicillin Feasible?

Results of a Pilot Study

Jody R. Murph, M.D., M.S.

Department of Pediatrics, The University of lowa, Iowa City, Iowa

Lois B. Dusdieker, M.D.

Department of Pediatrics, The University of lowa, Iowa City, Iowa

Brenda Booth, Ph.D.

Veterans Administration Medical Center, Iowa City, Iowa

William E. Murph, Murph

Department of Preventive Medicine and Environmental Health, The University of Iowa, Iowa City, Iowa

We report a study of the feasibility of once-a-day amoxicillin to treat acute otitis media (AOM). Seventy-seven children between ages 7 months and 12 years with AOM participated in a double-blind, placebo-controlled trial. Subjects received amoxicillin 40 mg/kg/day for 10 days. They were similar in age, sex, history of ear infections, and presenting symptoms. Group I received one total dose of amoxicillin and two doses of placebo daily. Group II received three divided doses of amoxicillin daily. Parents kept a daily diary of symptoms related to the child's illness and possible medication side effects. Ten children were lost to follow-up. In the remaining 67, pneumatic otoscopy and tympanometry after 10 to 14 days revealed that AOM had resolved in 82% of group I and 68% of group II. Groups showed no significant differences in persistence of middle ear effusion; 39% in group I and 24% in group II still had fluid. Diaries showed no significant differences between groups in medication side effects. Thus, reduced-frequency dosing for AOM seems feasible and more realistic than current regimens.

Clinical Pediatrics, Vol. 32, No. 9, 528-534 (1993)
DOI: 10.1177/000992289303200904
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