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Clinical Pediatrics
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Notes

Congenital Syphilitic Skeletal Manifestations in a Premature Infant Revisited

Nestor B. Ilagan, M.D.

Department of Pediatrics, Grace Hospital Wayne State University Detroit, Michigan

Burt Weyhing, M.D.

Department of Radiology, Grace Hospital Wayne State University Detroit, Michigan

Keh-Chyang Liang, M.D.

Department of Pediatrics Grace Hospital Wayne State University Detroit, Michigan

Sophie J. Womack, M.D.

Department of Pediatrics Grace Hospital Wayne State University Detroit, Michigan

Seetha Shankaran, M.D.

Department of Pediatrics Grace Hospital Wayne State University Detroit, Michigan

Increasing rates of congenital syphilis have been reported in recent years despite the availability of adequate therapy. In our perinatal-neonatal center, approximately 1.5 % of newborns have reactive serologic tests for syphilis.1 Untreated or partly treated maternal syphilis can adversely affect neonatal outcome since the treponeme can cross the placenta at any time during pregnancy. 2 As a result of hematogenous placental transmission, neonatal manifestations are usually systemic and similar to the secondary stage of syphilis, and include hepatosplenomegaly, jaundice, neuro-syphilis, and skeletal changes. A case of early congenital syphilis in an extremely premature infant with primary skeletal involvement is presented.

Clinical Pediatrics, Vol. 32, No. 5, 312-313 (1993)
DOI: 10.1177/000992289303200514
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