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Clinical Pediatrics
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*Sickle Cell Anemia
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Survey of Pain Management Therapy Provided for Children With Sickle Cell Disease

Charles H. Pegelow, M.D.

Department of Pediatrics (R-131), University of Miami School of Medicine, P.O. Box 016960, Miami, FL 33101

A questionnaire was sent to principal investigators of NIH-sponsored clinical research in sickle cell disease. Twenty of 21 respondents indicated they used parenteral narcotic analgesics for pain episodes sufficiently severe to warrant hospitalization. Eleven used meperidine; seven, morphine; and one each, nalbuphine, hydromorphone, and acetaminophen with codeine. They gave the agents at frequent, regular intervals or by continuous infusion. A total of 41 of more than 3,500 patients required chronic transfusion for pain control. Complications included meperidine-associated convulsions reported by nine respondents and addiction by six. This information indicates that vigorous pain-control methods are used at institutions having a special interest in providing medical care for children with sickle cell disease.

Clinical Pediatrics, Vol. 31, No. 4, 211-214 (1992)
DOI: 10.1177/000992289203100404
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