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Clinical Pediatrics, Vol. 31, No. 11, 642-649 (1992)
DOI: 10.1177/000992289203101101

Explanations and Therapies for Penicillin Failure in Streptococcal Pharyngitis

Michael E. Pichichero, M.D.

Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 (716)275-5944

A disturbing trend toward penicillin failure has developed in the treatment of streptococcal pharyngitis in some parts of the United States and abroad. A variety of explanations has been proposed to account for these penicillin-treatment failures. With the resurgence of serious complications from streptococcal infection, successful bacteriologic eradication has regained importance. In communities with a high incidence of penicillin failures, alternative antimicrobials should be considered. Cephalosporins, amoxicillin/clavulanate, and the extended-spectrum macrolides represent logical options under such clinical circumstances.


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M. E. Pichichero
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