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Clinical Pediatrics
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Factor VIII Related Antigen (von Willebrand's Factor) In Kawasaki Disease

Jose E. Irazuzta, MD

The Children's Hospital, 300 Longwood Avenue, Boston, MA 02115

Francisco Elbl, MD

Department of Pediatrics, School of Medicine, University of Louisville and Kosair Children's Hospital, Louisville, Kentucky

Allan R. Rees, MD

Department of Pediatrics, School of Medicine, University of Louisville and Kosair Children's Hospital, Louisville, Kentucky

Kawasaki disease is a systemic vasculitis in which secondary development of coronary artery aneurysms can occur. Because Factor VIII related antigen has been found increased in other vasculiditides, VIII R:Ag was measured serially in patients with Kawasaki disease.

Factor VIII related antigen was prospectively evaluated in the acute phase of ten patients with Kawasaki disease, all of whom showed increased values at this stage (p > 0001). In six children a second sample was drawn at the convalescent phase, and all were normal. Of the original ten patients, two developed coronary artery aneurysms. Acute Factor VIII related antigen levels were not higher nor did Factor VIII related antigen fail to return to baseline in these two patients.

Based on our findings, Factor VIII related antigen is elevated in the acute phase of Kawasaki disease and returns to normal levels in the convalescent phase.

Clinical Pediatrics, Vol. 29, No. 6, 347-348 (1990)
DOI: 10.1177/000992289002900613
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[Abstract] [PDF]