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Clinical Pediatrics
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Serum Carotene Concentrations in Normal Infants and Children

Alexander K.C. Leung, MBBS, FRCPC, FRCP (Edin), FRCP (Glasg), FRCPI, FAAP, DCH

Departments of Pediatrics, Alberta Children's Hospital, 1820 Richmond Road SW, Calgary, Alberta, Canada. T2T5C7

T. Oswald Siu, MD

Community Health, the University of Calgary, Calgary, Alberta, Canada

Anthony S.K. Chiu, MD

Grace Hospital, Calgary, Alberta, Canada

Wm. Lane M. Robson, MD, FRCPC

Alberta Children's Hospital, Calgary, Alberta, Canada

Trygve E. Larsen, MD, FRCPC

Calgary Medical Laboratories, Calgary, Alberta, Canada

The blood of 444 healthy Canadian children (246 males and 198 females) aged 6 days to 18 years was analyzed to determine the concentration of serum carotene. The serum carotene concentration was very low in the first six months of life. In the first three months of life, breast fed infants had significantly higher serum carotene concentration than infants who were formula fed. Infants 7 to 12 months of age had the highest serum carotene concentration. The serum carotene concentration dropped off after the age of one year and remained low until two years of age. After two years of age, the serum carotene concentration showed a progressive and small rise until the age of six to seven years and then fell until the age of 14 to 18 years. The serum carotene concentration did not appear to vary according to the sex of the child except for infants 7 to 12 months of age. In infants 7 to 12 months of age, girls had a higher serum carotene concentration. The measurement of the serum carotene concentration is a simple screening test for fat malabsorption. Our study provides the normal range of serum carotene concentration for children of various age groups.

Clinical Pediatrics, Vol. 29, No. 10, 575-578 (1990)
DOI: 10.1177/000992289002901004
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