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Clinical Pediatrics
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Relapsing Post-hepatitis Aplastic Anemia

Immunosuppressive Therapy

Kevin Shannon, MD

Department of Pediatrics, University of California School of Medicine, San Francisco, CaliforniaThe Romie Lane Pediatric Group, Salinas, California

William Koehne, MD

Department of Pediatrics, University of California School of Medicine, San Francisco, CaliforniaThe Romie Lane Pediatric Group, Salinas, California

Melvin B. Heyman, MD

Department of Pediatrics, University of California School of Medicine, San Francisco, CaliforniaThe Romie Lane Pediatric Group, Salinas, California

Marion A. Koerper, MD

Department of Pediatrics, University of California School of Medicine, San Francisco, CaliforniaThe Romie Lane Pediatric Group, Salinas, California

A 20-month-old Hispanic male developed severe aplastic anemia after an episode of non-A, non-B hepatitis. Prompt and complete recovery of all hematopoietic cell lines occurred after treatment with antithymocyte globulin (ATG) and high-dose corticosteroids. Severe aplasia recurred two months later coincident with a mild upper respiratory infection. A second course of immunosuppressive therapy was followed by complete, sustained improvement. The authors' experience provides clinical evidence indicating that immunologic mechanisms are important in the treatment of severe post-hepatitis aplastic anemia. Children in whom aplastic anemia recurs after immunosuppressive treatment may respond to a second course of therapy.

Clinical Pediatrics, Vol. 29, No. 1, 25-29 (1990)
DOI: 10.1177/000992289002900103
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