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Clinical Pediatrics, Vol. 28, No. 12, 585-588 (1989)
DOI: 10.1177/000992288902801208

Peripheral Limb Gangrene Following Rectal Biopsy

Treatment with Prostacyclin and Exchange Transfusion

B.R. Jani, MB, BCh

Queen Elizabeth Hospital for Children, London, England

R.J. Brereton, FRCS

Queen Elizabeth Hospital for Children, London, England

M.J. Dillon, FRCP

Queen Elizabeth Hospital for Children, London, England

After a rectal biopsy, a 3-week-old boy developed centripetally progressive distal limb gangrene. This was accompanied by transient hypertension and high levels of circulating immune complexes. The ischemia was reversed by prostacyclin infusion, oral corticosteroids and multiple exchange transfusions.


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