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Clinical Pediatrics, Vol. 27, No. 7, 344-347 (1988)
DOI: 10.1177/000992288802700707

Aldosterone-producing Adenoma Presenting with Hypokalemic Myopathy

Case Report and Review

Bryan A. Dickson, MD

Department of Pediatrics, The University of Texas Health Science Center, San Antonio, Texas.

Robert C. Franks, MD

Department of Pediatrics, The University of Texas Health Science Center, San Antonio, Texas.

A 9-year-old boy who complained of fatigue, myalgias, and progressive weakness was found to have a markedly elevated serum creatine phosphokinase (CPK). He developed polyuria with polydipsia and was noted to be hypertensive and severely hypokalemic. Treatment with potassium and spironolactone alleviated his signs and symptoms and normalized the blood pressure and CPK.

Initial studies revealed low plasma renin activity that did not increase with change from supine to upright position. Plasma aldosterone was consistently elevated in the supine position, decreased with upright posture, and was not suppressed by administration of dexamethasone. Plasma 18-hydroxycorticosterone also was elevated.

Enhanced computerized tomography (CT) revealed a mass in the left adrenal that had not been seen on the initial unenhanced scan. Adrenal vein catheterization confirmed elevated plasma aldosterone on that side. Adrenalectomy was performed, and a well-encapsulated adenoma was found at examination of the surgical speciman. Postoperatively, suppression of plasma renin activity continued for many months without signs of aldosterone deficiency.


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