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Clinical Pediatrics
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Congenital Adrenal Hyperplasia Associated with Hyperphosphatemic Rickets

R. Dumas

Service de Pédiatrie, Hôpital Saint Charles, Montpellier

M. Garabedian

Unité d'Inserm 30, Hôpital des Enfants Malades, Paris

C. Belon

Laboratoire de Biochimie, Faculté de Pharmacie, Montpellier, France

C. Sultan

Service de Pédiatrie, Hôpital Saint Charles, Montpellier

P. Garandeau

Service de Pédiatrie, Hôpital Saint Charles, Montpellier

A. Naoumis

Service de Pédiatrie, Hôpital Saint Charles, Montpellier

The authors describe a boy with precocious puberty due to adrenal hyperplasia associated with rickets, hypocalcemia, hyperphosphatemia, elevated PTH and alkaline phosphatase levels, and concentrations of 25-OH-D and 1,25-(OH)2D at the upper limit or above normal range. Treatment with hydrocortisone for 9 months did not normalize hypocalcemia and hyperphosphatemia. The addition of 1,25-(OH)2D3 (0.5-2 µg/day) to the corticoid treatment for 1 year was followed by a progressive normalization of plasma calcium, phosphorus, PTH and alkaline phosphatase concentrations with improvement of the osteomalacia on bone biopsy.

Clinical Pediatrics, Vol. 27, No. 6, 276-278 (1988)
DOI: 10.1177/000992288802700602
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