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Clinical Pediatrics
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Application of Pharmacokinetics in the Diagnosis of Chemical Abuse in Münchausen Syndrome by Proxy

Vinit K. Mahesh

Department of Pediatrics, University of Arkansas for Medical Sciences

H. Patrick Stern

Department of Pediatrics, University of Arkansas for Medical Sciences, Department of Psychiatry and Behavioral Science, University of Arkansas for Medical Sciences, Divisions of Behavioral Pediatrics, Arkansas Children's Hospital

Gregory L. Kearns

Department of Pediatrics, University of Arkansas for Medical Sciences, Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Critical Care Medicine, Arkansas Children's Hospital, Little Rock, Arkansas

Suzanne E. Stroh

Divisions of Behavioral Pediatrics, Arkansas Children's Hospital

The case of a preschooler who was chemically abused in Münchausen syndrome by proxy is presented. Though there were many clinical characteristics that raised suspicions of this syndrome, the definitive diagnosis was made by the application of pharmacokinetics during a hospital admission. This is the first reported use of this diagnostic approach to confirm this elusive disorder. Standard pharmacological equations can be used to provide this information from pharmacokinetic data which are readily available in most hospital settings.

Clinical Pediatrics, Vol. 27, No. 5, 243-246 (1988)
DOI: 10.1177/000992288802700507
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