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Clinical Pediatrics, Vol. 27, No. 2, 63-68 (1988)
DOI: 10.1177/000992288802700201

Long-term Prognosis for Children With Nephrotic Syndrome

Susan R. Wynn, MD

Department of Pediatrics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Gunnar B. Stickler, MD

Department of Pediatrics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Edmund C. Burke, MD

Department of Pediatrics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Follow-up survival and health information were obtained, after a median of 27.5 years, from 132 patients who had been seen originally as children with nephrotic syndrome between 1951 and 1967. Ninety seven patients were alive. Recurring edema or proteinuria, or both, persisted in 15 percent of those still alive. Eight of 11 parous women reported relapses during pregnancy. There was no apparent increase in malignancies, atopic diseases, clinical defects in cell-mediated immunity, or cardiovascular diseases.

Twenty two patients (17%) died of renal causes between 3 months and 8 years after the onset of nephrotic syndrome. Steroid resistance was the presenting feature universally predictive of a poor outcome; nine of the 11 such patients died and the other two are now receiving hemodialysis. Hematuria was present initially in 41 percent of the patients who died of renal causes, compared with 14 percent of those still alive. Hypertension was noted on the first examination in 22 percent of those who died of renal causes, compared with 10 percent of those alive.


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