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Clinical Pediatrics
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Multiple Sclerosis Presenting at 4 Years of Age: Clinical and MRI Correlations

Francis J. DiMario, JR, MD

Division of Pediatric Neurology, Children's Hospital of Philadelphia, and the Department of Neurology and Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania

Peter H. Berman, MD

Division of Pediatric Neurology, Children's Hospital of Philadelphia, and the Department of Neurology and Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania

The authors present a patient with multiple sclerosis (MS) whose onset of illness was at 4 years of age. Three separate and distinct episodes of central nervous system (CNS) dysfunction associated with cerebrospinal fluid (CSF) pleocytosis, electroencephalographic (EEG) abnormalities, and extensive CNS white matter demyelination on both computerized tomography (CT) and magnetic resonance imaging (MRI) characterized her clinical course. Two episodes responded well to prednisone therapy.

Clinical Pediatrics, Vol. 27, No. 1, 32-37 (1988)
DOI: 10.1177/000992288802700107
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[Abstract] [PDF]