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Clinical Pediatrics
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Paroxysmal Nocturnal Hemoglobinuria Presenting As Recurrent Hemolytic Uremic Syndrome

Morris Kletzel

Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas

Watson C. Arnold

Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas

Daisilee H. Berry

Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas

Paroxysmal nocturnal hemoglobinuria (PNH) may present with acute anemia, thrombocytopenia and, if hemoglobin nephropathy or dehydration is present, azotemia. Thus PNH may be confused with the hemolytic uremic syndrome (HUS). Recurrent episodes, though common in PNH, are unusual in HUS. A positive acid hemolysis test can be used to differentiate between the two diseases.

Clinical Pediatrics, Vol. 26, No. 6, 319-320 (1987)
DOI: 10.1177/000992288702600613
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