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Clinical Pediatrics
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The Use of a Rapid Theophylline Assay in the Ambulatory Setting

Paul J. Munzenberger

From the Departments of Pharmacy Practice and Pediatrics, Wayne State University, Department of Pharmacy and Division of Allergy, Children's Hospital of Michigan, Detroit, Michigan

Neil Massoud

From the Departments of Pharmacy Practice and Pediatrics, Wayne State University, Department of Pharmacy and Division of Allergy, Children's Hospital of Michigan, Detroit, Michigan

Helen A. Papaioanou

From the Departments of Pharmacy Practice and Pediatrics, Wayne State University, Department of Pharmacy and Division of Allergy, Children's Hospital of Michigan, Detroit, Michigan

The Seralyzer reflectance photometer was evaluated in three ambulatory settings. Of the total 99 assays in the pediatric general medicine clinic, 47 were below the therapeutic range, and 20 patients were noncompliant. There were 13 low and nine high levels along with 22 noncompliant patients detected from a total of 109 in the allergy clinic. The physician's office documented 43 low and four high levels along with 10 noncompliant patients from 105 assays. The mean time required for Seralyzer results in both the allergy and pediatric general medicine clinic was 13 minutes. Regression analysis of both finger-stick and venipuncture split samples indicated a strong correlation between Seralyzer results and traditional methods of assay (r = 0.94 and 0.99, respectively). The Seralyzer proved accurate, timely, and simple to operate.

Clinical Pediatrics, Vol. 25, No. 9, 448-452 (1986)
DOI: 10.1177/000992288602500907
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