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Persistent Hypertransaminasemia as the Presenting Finding of Childhood Muscle Disease

Department of Pathology, Children's Medical Center, 1935 Amelia Street, Dallas, TX 75235

John Andersen

From the Departments of Pathology, Pediatrics, and Neurology, The University of Texas Health Science Center at Dallas, Dallas, Texas.

Chester W. Fink

From the Departments of Pathology, Pediatrics, and Neurology, The University of Texas Health Science Center at Dallas, Dallas, Texas.

Jay Cook

From the Departments of Pathology, Pediatrics, and Neurology, The University of Texas Health Science Center at Dallas, Dallas, Texas.

Alan Strickland

From the Departments of Pathology, Pediatrics, and Neurology, The University of Texas Health Science Center at Dallas, Dallas, Texas.

Four children with isolated, persistent elevations of serum transaminases were investigated for hepatic disease and followed for 4 to 24 months before serum creatine kinase determinations were obtained and found to be markedly elevated. Evidence of muscle disease was obtained by close questioning, retrospectively, and mild abnormalities were found on physical examination. Review of laboratory tests in our center for 6 months revealed 30 additional cases of anicteric hypertransaminasemia (20% of those with elevated enzymes), only two of which were unexplained by the admitting diagnosis.

Serum transaminase values are elevated in a variety of diseases of different organ systems. Creatine kinase determinations may provide the clue to the diagnosis of occult muscle disease in some children with unexplained anicteric hypertransaminasemia.

Clinical Pediatrics, Vol. 24, No. 9, 500-503 (1985)
DOI: 10.1177/000992288502400906


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