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Clinical Pediatrics
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*VALPROIC ACID
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Acute Valproic Acid Toxicity at Therapeutic Concentrations

Suman Wason

Children's Hospital Research Foundation, Elland and Bethesda Avenues, Cincinnati, OH 45229

Daniel Savitt

From the Department of Pediatrics, the Divisions of Ambulatory Services, Children's Hospital Medical Center, and Emergency Medicine, University of Cincinnati, Cincin- nati, Ohio.

A previously healthy nonepileptic 11-year-old girl presented with confusion and disorientation after an acute ingestion of valproic acid. Her serum concen tration of valproic acid was 39.6 mcg/ml, a range normally considered "thera peutic" in the control of seizures. She recovered without sequelae despite the subsequent attainment of higher valproic acid concentrations.

Clinical Pediatrics, Vol. 24, No. 9, 466-467 (1985)
DOI: 10.1177/000992288502400901
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