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DOI: 10.1177/000992288502400705 Rubella Seronegativity in a Low Socioeconomic Adolescent Female PopulationFrom the Department of Pediatrics, Division of Adolescent Medicine, University of California School of Medicine and Medical Center. San Diego. California.
From the Department of Pediatrics, Division of Adolescent Medicine, University of California School of Medicine and Medical Center. San Diego. California.
University of California San Diego Medical Center, 225 Dickinson Street, H814-F, San Diego. CA 92103
Ninety low socioeconomic adolescent females (aged 16-22 years, x 18.6 years) were screened for rubella immunity using a rubella IgG enzyme immunoassay. Data concerning past immuni zations (with documentation, if possible), prior rubella disease, and previous pregnancies were gathered through direct interviews. Results revealed 20 percent (18/90 girls) were seronegative. Fifty-eight percent (42/72) of the seropositive girls and 50 percent (9/18) of the seronegative girls gave verbal reports of previous rubella immunization, but only 11 subjects (12.2%) could provide documentation of previous vaccination, including one seronegative subject. Thirty-one percent (28/90) of the study population had a history of one or more previous pregnancies (22 therapeutic abortions, 10 live births, and 8 spontaneous abortions). A comparison of the seronegativity rate between the 28 girls who were pregnant previously and the 62 girls who were never pregnant demonstrated a significantly higher seronegativity rate among those who had been pregnant (29% vs. 16%;
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2 = 5.51; p < 0.05). The results of this study suggest that 1) the seronegativity rate in this age group is consistent with previous reports of rubella immunity, 2) few adolescents can provide documentation of rubella vaccination, and 3) presentation for abortion is an optimal time to vaccinate rubella susceptible females.