Clinical Pediatrics

 

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Clinical Pediatrics, Vol. 24, No. 5, 256-258 (1985)
DOI: 10.1177/000992288502400504

Significance of Placental Findings in Early-Onset Group B Streptococcal Neonatal Sepsis

Robert W. Novak

Children's Hospital Medical Center, 281 Locust Street, Akron, OH 44308

Marvin S. Platt

Assessment of placental pathology and its relationship to historical data, initial laboratory parameters, and outcome was undertaken in 22 cases of early-onset group B streptococcal sepsis of the neonate. Fourteen (64%) of the placentas demonstrated chorioamnionitis, six (27%) funisitis, and in nine (41%) gram stain demonstrated organisms within the membranes. Focal villous edema was observed in five (23%) cases and diffuse villous edema in four (18%). No placenta demonstrated chorangiosis. Placental inflammation was significantly (p < 0.05) associated with prematurity, prolonged rupture of membranes, and onset of symptoms at less than 3 hours of age. No placental change was significantly associated with outcome or with neutropenia, which was the only parameter assessed that appeared to have prognostic value.


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