Clinical Pediatrics

 

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Clinical Pediatrics, Vol. 24, No. 3, 168-170 (1985)
DOI: 10.1177/000992288502400314

Neonatal Theophylline Neurotoxicity

Robert R. Clancy

The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104.

Karen M. Kaplan

Stephen Baumgart

Kathleen R. Rosenberry

Despite the frequency with which theophylline is administered to premature infants, there are few reported cases of neurotoxicity. We describe a theophylline- treated premature infant with chronic bronchopulmonary dysplasia and hepatitis who displayed a focal seizure and irritability followed by other systemic signs of theophylline intoxication, at a postnatal age of 5 months. An unrecognized accidental drug overdose combined with a prolonged elimination half-life were responsible for clinical intoxication. The potential mechanisms of theophylline's neurotoxicity are discussed briefly.


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