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Clinical Pediatrics, Vol. 24, No. 2, 69-73 (1985)
DOI: 10.1177/000992288502400201

Incidence of Hyperbilirubinemia in Breast- vs. Formula-fed Infants

Joyce A. Adams, MD

Department of Pediatrics, The University of Health Sciences, Kansas City, Missouri

Dennis J. Hey, DO

Department of Pediatrics, The University of Health Sciences, Kansas City, Missouri

Robert T. Hall, MD

Department of Pediatrics, The University of Health Sciences, Kansas City, Missouri

A retrospective study of 233 consecutively born full-term infants was performed to determine the effect of several variables on the development of hyperbilirubinemia. Thirty-five (15%) of the infants developed peak bilirubin levels greater than 12 mg/dl in the first week of life. Step wise multiple regression analysis revealed that breast-feeding was the most predictive of a group of eight variables for the development of hyperbilirubinemia greater than 12 mg/dl. The correlation between type of feeding and hyperbilirubinemia was significant (p < 0.02). None of the other factors evaluated was significantly associated with hyperbilirubinemia.

Breast-fed infants also were found to have a significantly higher incidence of hyperbilirubinemia greater than 15 mg/dl; 12 of 101 (12%) infants compared with 2 of 117 (2%) formula-fed infants (p < 0.002). This group of infants accounted for the increased incidence of hyperbilirubinemia greater than 12 mg/dl in breast-fed infants.

There was no significant correlation between weight loss and development of hyperbilirubinemia in the breast-fed infants.


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