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Clinical Pediatrics
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Gastrointestinal Dialysis with Activated Charcoal and Cathartic in the Treatment of Adolescent Intoxications

Howard C. Mofenson, MD

Long Island Regional Poison Control Center (LIRPCC), Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554

Thomas R. Caraccio, PharmD

Long Island Regional Poison Control Center (LIRPCC), Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554

Joseph Greensher, MD

Long Island Regional Poison Control Center (LIRPCC), Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554

Ronald D'Agostino, BS

Long Island Regional Poison Control Center (LIRPCC), Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554

Anthony Rossi, MD

Long Island Regional Poison Control Center (LIRPCC), Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554

This article reports five patients who had taken a substantial medication overdose and presented in coma. Two had taken a salicylate overdose and three a phenobarbital overdose (one of these ingested a combination of phenobarbital and phenytoin). The cases were treated by our standard protocol of supportive therapy and alkaline diuresis plus repetitive oral doses of activated charcoal (gastrointestinal dialysis). All patients were alert and oriented within 24 hours. Toxicokinetic analysis of the blood levels is discussed. Gastrointestinal dialysis represents a relatively noninvasive method that may benefit certain intoxicated patients even after systemic absorption has occurred. The technique and recommendations for its use are discussed and described in detail.

Clinical Pediatrics, Vol. 24, No. 12, 678-684 (1985)
DOI: 10.1177/000992288502401202
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Home page
 Arch Intern MedHome page
L. A. Kirshenbaum, S. C. Mathews, D. S. Sitar, and M. Tenenbein
Does Multiple-Dose Charcoal Therapy Enhance Salicylate Excretion?
Arch Intern Med, June 1, 1990; 150(6): 1281 - 1283.
[Abstract] [PDF]