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Clinical Pediatrics
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*Asthma
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*THEOPHYLLINE
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Cardiopulmonary Responses of Asthmatic Children to Strenuous Exercise

Effect of Theophylline

C. Chryssanthopoulos

Departments of Pediatrics and Pathology, The Medical College of Wisconsin, Milwaukee and the University of Wisconsin, Milwaukee, Wisconsin

M.G. Maksud

Departments of Pediatrics and Pathology, The Medical College of Wisconsin, Milwaukee and the University of Wisconsin, Milwaukee, Wisconsin

W.G. Gallen

Departments of Pediatrics and Pathology, The Medical College of Wisconsin, Milwaukee and the University of Wisconsin, Milwaukee, Wisconsin

L.L. Hause

Departments of Pediatrics and Pathology, The Medical College of Wisconsin, Milwaukee and the University of Wisconsin, Milwaukee, Wisconsin

The purposes of the study were to investigate the cardiopulmonary adaptations of asthmatic children to physical exercise and to evaluate the effects of theophylline. Two groups of children were evaluated.

Eight asthmatic children participated in two exercise sessions. Half of the patients received theophylline in predetermined doses during the first session and half prior to the second session. Seventeen normal children matched for age, height, and weight served as controls. Various car diorespiratory parameters were measured every 2 minutes during exercise and prior to termination of maximal physical effort.

The results indicate that children with chronic asthma reach the range of predicted maximal aerobic capacity for their age. Theophylline increases the endurance of asthmatic children to maximal physical efforts without improving the cardiorespiratory parameters that were measured. The use of theophylline in therapeutic doses appears safe under conditions of vigorous exercise.

Clinical Pediatrics, Vol. 23, No. 7, 384-388 (1984)
DOI: 10.1177/000992288402300704
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