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Clinical Pediatrics, Vol. 23, No. 3, 184-187 (1984)
DOI: 10.1177/000992288402300312

Retinoblastoma Metastatic to Bone Marrow

A Case with Florid Spread

Henry S. Friedman

P.O. Box 2916, Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC 27710

Joanne Kurtzberg

Departments of Pediatrics and Pathology, Duke University Medical Center, Durham, North Carolina.

Byron Croker

Departments of Pediatrics and Pathology, Duke University Medical Center, Durham, North Carolina.

John M. Falletta

Departments of Pediatrics and Pathology, Duke University Medical Center, Durham, North Carolina.

Thomas R. Kinney

Departments of Pediatrics and Pathology, Duke University Medical Center, Durham, North Carolina.

A 28-month-old white male, 7 months status postenucleation for retinoblastoma, presented with lethargy, irritability, anemia, and thrombocytopenia. Bone marrow examination revealed almost total replacement of marrow elements with clumps of small round basophilic cells. Electron microscopic study of the marrow revealed clumps of cohesive tumor cells with intermediate junctions, establishing a diagnosis of metastatic retinoblastoma.


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