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Clinical Pediatrics, Vol. 23, No. 3, 154-156 (1984)
DOI: 10.1177/000992288402300304

The Effect of Neonatal Hyperbilirubinemia on the Measurement of Plasma Creatinine

Leonard G. Feld

Divisions of Pediatric Nephrology and Neonatology, Department of Pediatrics, Albert Einstein College of Medicine and the Bronx Municipal Hospital Center, Bronx, New York.

Daniel J. Langford

Divisions of Pediatric Nephrology and Neonatology, Department of Pediatrics, Albert Einstein College of Medicine and the Bronx Municipal Hospital Center, Bronx, New York.

George J. Schwartz

Rose F. Kennedy Center, Room 721, 1410 Pelham Parkway South, Bronx, New York 10461

Bilirubin interferes with the measurement of plasma creatinine by the kinetic colorimetric Jaffe reaction, the method currently used by many hospital laboratories. The purpose of the present study was to evaluate the influence of unconjugated bilirubin on the measurement of plasma creatinine by the AutoAnalyzer Jaffe end point method. This colorimetric method is slower but more precise and accurate in the range of 0.25 to 0.5 mg/dl. We found that bilirubin from jaundiced neonates and from stock solutions did not affect the determination of creatinine chro mogen in plasma or in saline, even at concentrations as high as 25 mg/dl. We conclude that the use of the Jaffe end point AutoAnalyzer method with a blank run before each sample will provide an accurate measurement of creatinine in the plasma of the neonate with unconjugated hyper bilirubinemia.


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