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Clinical Pediatrics
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*Growth Disorders
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*LEVOTHYROXINE
*LIOTHYRONINE
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Familial Growth Retardation with Isolated Thyroid-Stimulating Hormone Deficiency

A. Labbe

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

C. Dubray

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

G. Gaillard

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

G. Besse

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

P. Assali

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

G. Malpuech

From the Department of Pediatrics and the Laboratory of Radioimmunology, Hotel-Dieu, Clermont-Ferrand, France

Three brothers with isolated thyroid-stimulating hormone (TSH) deficiency were observed at ages 17, 15, and 10 years. They suffered from severely retarded growth, with a marked retardation in bone maturation. Their serum T4, T3, and TSH levels were low. Serum thyrotropin-releasing hormone (TRH) concentration was normal. No increases in TSH levels were elicited during the TRH test. The other pituitary hormones, adrenocorticotropic hormone, growth hormone, follicle-stimulating hormone, luteinizing hormone, and prolactin hormone, responded normally to stimulation. Thyroxin treatment triggered a growth acceleration. Genetic investigation revealed several instances of small stature on the father's side.

Clinical Pediatrics, Vol. 23, No. 12, 675-678 (1984)
DOI: 10.1177/000992288402301202
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