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Clinical Pediatrics
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*Compound via MeSH
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*AMIKACIN
*SULFAMETHOXAZOLE
*TRIMETHOPRIM
*TRIMETHOPRIM/SULFAMETHOXAZOLE
Medline Plus Health Information
*Encephalitis
*Infant and Toddler Health
*Meningitis
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Citrobacter Ventriculitis in a Neonate Responsive to Trimethoprim-sulfamethoxazole

Gerald R. Greene

Department of Pediatrics, University of California, Irvine, College of Medicine, Irvine, California

Leo Heitlinger

Department of Pediatrics, University of California, Irvine, College of Medicine, Irvine, California

John D. Madden

Department of Pediatrics, University of California, Irvine, College of Medicine, Irvine, California

There are increasing reports of citrobacter central nervous system infections in neonates. These organisms cause brain abcesses in a high percentage of pa tients. They may be resistant to commonly used antibiotics. We report a term male infant with underlying meningo-myelocoele and hydrocephalus in whom Citrobacter diversus meningitis and ventriculitis developed. Initial antibiotic ther apy including intraventricular amikacin failed to sterilize the ventricles or alter a deteriorating clinical course. Adding intravenous trimethoprim-sulfamethox azole to the therapeutic regimen resulted in reversal of a progressively worsening condition and eventual recovery. Trimethoprim-sulfamethoxazole should be con sidered as a potentially useful alternative antibiotic for susceptible central ner vous system infections.

Clinical Pediatrics, Vol. 22, No. 7, 515-517 (1983)
DOI: 10.1177/000992288302200711
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