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Clinical Pediatrics
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Comparison of Salivary Concentrations of Rifampin and Cefaclor

A Rationale for Chemoprophylaxis of Hemophilus influenzae type b Disease

Charles M. Ginsburg

Department of Pediatrics, The University of Texas Health Science Center at Dallas, Dallas, Texas

George H. McCracken, JR

Department of Pediatrics, The University of Texas Health Science Center at Dallas, Dallas, Texas

Cefaclor and rifampin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an expla nation of the efficacy of rifampin and the inability of cefacior to eradicate pharyngeal carriage of Hemophilus strains.

Clinical Pediatrics, Vol. 21, No. 7, 397-399 (1982)
DOI: 10.1177/000992288202100702
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?