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Clinical Pediatrics, Vol. 21, No. 6, 360-364 (1982)
DOI: 10.1177/000992288202100607

Systemic Hemophilus influenzae Infection

A Study of Risk Factors

Stephen J. Lerman, M.D.

Departments of Pediatrics and Medical Microbiology, College of Medicine, University of Nebraska, Omaha Nebraska

In Omaha, from 1974 to 79, 30 (12.5%) of 240 patients with Haemophilus influenzae bacteremia or meningitis had a wide variety of conditions known to be associated with increased susceptibility to bacterial infection. Neonates and adults accounted for 47 per cent of the infections. Non-type b and non-typable strains caused 41 per cent of the episodes. Forty-one per cent of patients had bacteremia with no detectable focus of infection. The incidence of meningitis was low. Mortality was 28 per cent, considerably higher than in patients who were previously healthy.

A review of the medical literature indicated that low-birth weight infants and patients with leukemia and other malignancies undergoing chemotherapy, splenectomy, congenital asplenia, sickle cell anemia, immunoglobulin deficiency diseases, cerebrospinal fluid shunts, and skull de fects are at greater risk for systemic H. influenzae disease than the general population.


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S. R. Nesheim and W. D. Wilcox
Systemic Hemophilus Influenzae Disease in Children: A 10-Year Retrospective Study of an Urban Hospital Population
Clinical Pediatrics, December 1, 1986; 25(12): 605 - 609.
[Abstract] [PDF]