Clinical Pediatrics

 

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Clinical Pediatrics, Vol. 21, No. 4, 236-238 (1982)
DOI: 10.1177/000992288202100408

Concordant Optic Glioma in a Pair of Monozygotic Twins with Neurofibromatosis

Sheila C. Cartwright

Leeds Regional Radiotherapy Centre, Cookridge Hospital, Leeds, England

The occurence is reported of optic chiasma gliomas in a pair of identical twins, both with neurofibromatosis. One twin developed precocious puberty in the sixth year of life and was shown by cisternal computerized tomography to have a su prasellar tumor, which proved to be a malignant glioma. The second twin had an abnormal growth spurt but not overt precocious puberty. Cisternal computerized tomography of the second twin revealed evidence of a similar, smaller tumor at the same site. The literature is reviewed and some possible genetic explanations discussed. This report also emphasises the importance of careful investigation of the second twin when a malignancy is found in one, irrespective of the site or type of the tumor.


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