Clinical Pediatrics

 

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Clinical Pediatrics, Vol. 21, No. 4, 225-227 (1982)
DOI: 10.1177/000992288202100405

A Microtechnique for Radioisotopic Determination of Glomerular Filtration Rate in Infants and Children

Victor Braren

Department of Urology, Vanderbilt University Medical Center and Vanderbilt Childrens Hospital

A. Bertrand Brill

Division of Nudear Medicine, the Department of Radiology, Vanderbilt University Medical Center and Vanderbilt Childrens Hospital, Nashville, Tennessee

Juan Touya

Division of Nudear Medicine, the Department of Radiology, Vanderbilt University Medical Center and Vanderbilt Childrens Hospital, Nashville, Tennessee

John Goddard

Division of Nudear Medicine, the Department of Radiology, Vanderbilt University Medical Center and Vanderbilt Childrens Hospital, Nashville, Tennessee

Our experience with a microtechnique using 99mTc-DTPA for determination of glomerular filtration rate in 172 children is presented. It is a simple finger-stick method carried out in a four-hour time period by trained nuclear medical per sonnel. The procedure meets all criteria for precise measurement of glomerular filtration rate, and the radiation dose is low. Proof of accuracy was obtained by comparison of this technique with concomitant 24-hour urinary creatinine clear ance in a subset of children.


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